Randox Research had the pleasure of attending the recent British Society of Immunology (BSI) Conference held in Brighton, UK. The BSI brings together academics performing research into infection and inflammation from across the UK and further afield.
Randox Research members Allen Huxley and Charlotte Manning had the pleasure of networking with academics in this varied field throughout the event, attending the highly informative and engaging presentations as well as showcasing Randox’s revolutionary multiplex biomarker technology.
The event started with a ‘bright sparks’ session during which numerous PhD students were able to provide a glimpse into their research as well as gaining valuable experience during their first steps into academic research. The keynote address was given by Professor Richard Flavell (Yale University) who gave an overview of the role of the gut microbiome in numerous disorders through a dysregulation of its interaction with the body’s traditional immune responses. The triumvirate of diet/microbiota/genotype all contribute to this dysregulation leading to inflammatory diseases such as Colitis, Inflammatory Bowel Disease and Crohns.
There were numerous other fascinating sessions throughout the following three days of the congress. Dr Leonie Taams (King’s College Hospital) chaired a very interesting session exploring the role of IL-17 which is a pro-inflammatory cytokine implicated in the immunopathology of several inflammatory diseases such as psoriasis rheumatoid arthritis and psoriatic arthritis (PsA). She explored how IL-17 producing CD8+ T cells are enriched in the joints of patients with PsA and that these cells correlate with the clinical parameters of disease. Professor Wedderburn (University College London) explored the role of Th17 cells in Juvenile Idiopathic Arthritis and how blocking IL-17 and IL-23 is increasingly considered as a therapeutic option in this condition.
Another excellent session centred on the immune responses associated with asthma. Professor von Mutius (Munich) showed how children who had a greater exposure to environmental microbial matter during infancy had a significantly lower prevalence of hay fever and asthma and was able to correlate this ‘protection’ with a different nose/throat microbiome compared to those affected children. Professor Mark Wilson (Imperial) discussed how atopic astmatic sufferers have a greater severity and duration of respiratory tract symptoms during Rhinovirus infection, essentially due to an impaired Interferon response which utilises the Th1 pathway. He hypothesised that this impaired Interferon response from asthmatics is due to an exacerbated Th2-type inflammatory response in these subjects.
The Randox Research Division would like to thank the BSI for organising such an excellent conference and giving us the opportunity to exhibit our range of products that have numerous applications in the immunology field.
To learn more about how Randox Research are improving clinical and research outcomes through the use of our award winning Multiplexing Biochip Array Technology view the Evidence Investigator Analyser page, alternatively download our Immunology Research brochure.